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PF-00446687 hydrochloride

CAS No. 862282-10-8

PF-00446687 hydrochloride( PF-446687 | PF00446687 )

Catalog No. M16241 CAS No. 862282-10-8

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PF-00446687 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
  • Description
    PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.Sexual Dysfunction Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF-446687 | PF00446687
  • Pathway
    GPCR/G Protein
  • Target
    Melanocortin Receptor
  • Recptor
    Melanocortin Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    862282-10-8
  • Formula Weight
    507.06
  • Molecular Formula
    C28H37ClF2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@@H]1CN(C(C)(C)C)C[C@H]1C2=CC=C(F)C=C2F)N3C[C@@H](C)[C@@](C4=CC=CC=C4)(O)[C@@H](C)C3.[H]Cl
  • Chemical Name
    (3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lansdell MI, et al. J Med Chem. 2010 Apr 22;53(8):3183-97. 2. Modi ME, et al. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.
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